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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS2
All Species:
31.82
Human Site:
Y605
Identified Species:
53.85
UniProt:
P54840
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54840
NP_068776.2
703
80989
Y605
W
R
Y
L
G
R
Y
Y
Q
H
A
R
H
L
T
Chimpanzee
Pan troglodytes
XP_520790
703
80912
Y605
W
R
Y
L
G
R
Y
Y
Q
H
A
R
H
L
T
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
Y605
W
K
Y
L
G
R
Y
Y
M
S
A
R
H
M
A
Dog
Lupus familis
XP_534869
703
80957
Y605
W
R
Y
L
G
R
Y
Y
Q
H
A
R
Y
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCB3
704
80866
Y605
W
R
Y
L
G
R
Y
Y
Q
H
A
R
H
L
T
Rat
Rattus norvegicus
P17625
704
80715
Y605
W
R
Y
L
G
R
Y
Y
Q
H
A
R
H
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
Y605
W
K
Y
L
G
R
Y
Y
M
F
A
R
H
M
A
Chicken
Gallus gallus
XP_416432
704
81032
Y606
W
R
Y
L
G
R
Y
Y
M
H
A
R
H
L
A
Frog
Xenopus laevis
NP_001084863
702
80811
R604
L
D
W
R
Y
L
G
R
F
Y
K
H
A
R
H
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
R603
L
D
W
R
Y
L
G
R
Y
Y
V
S
A
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
Q612
F
S
R
L
N
R
R
Q
R
I
I
Q
R
N
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
G570
V
E
D
H
E
Q
K
G
I
Y
V
I
D
R
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
L604
L
D
W
K
R
M
G
L
E
Y
V
K
A
R
Q
Red Bread Mold
Neurospora crassa
O93869
706
80888
Y595
W
K
R
M
G
M
E
Y
V
K
A
R
Q
L
A
Conservation
Percent
Protein Identity:
100
99.7
68.1
95.7
N.A.
94
93.3
N.A.
68
84.2
80.6
71.4
N.A.
56.9
N.A.
50.9
N.A.
Protein Similarity:
100
100
81.8
98.5
N.A.
96.5
96.3
N.A.
81.5
92.1
91.4
85.9
N.A.
73.9
N.A.
67.1
N.A.
P-Site Identity:
100
100
66.6
93.3
N.A.
100
100
N.A.
66.6
86.6
0
0
N.A.
13.3
N.A.
0
N.A.
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
80
86.6
13.3
13.3
N.A.
33.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49
50.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
66.8
67.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
40
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
65
0
22
0
29
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
22
8
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
8
0
0
8
0
8
0
8
0
0
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
65
0
22
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
43
0
8
50
0
15
% H
% Ile:
0
0
0
0
0
0
0
0
8
8
8
8
0
0
0
% I
% Lys:
0
22
0
8
0
0
8
0
0
8
8
8
0
0
0
% K
% Leu:
22
0
0
65
0
15
0
8
0
0
0
0
0
50
0
% L
% Met:
0
0
0
8
0
15
0
0
22
0
0
0
0
15
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
8
36
0
0
8
8
0
8
% Q
% Arg:
0
43
15
15
8
65
8
15
8
0
0
65
8
29
15
% R
% Ser:
0
8
0
0
0
0
0
0
0
8
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
36
% T
% Val:
8
0
0
0
0
0
0
0
8
0
22
0
0
0
0
% V
% Trp:
65
0
22
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
58
0
15
0
58
65
8
29
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _